3142749-82-1
3142749-82-1
Chemical Structure
GPR84 antagonist 11
- CAS No.: 3142749-82-1
- Formula:C21H28N2O3
- Molecular Weight:356.46
InChIKey: SXIWGVKUWAOPIO-HBFSDRIKSA-N
SMILES: O=C(NCC1CCCCC1)[C@H]2[C@]3([H])COC4=CC=CC=C4[C@]3([H])N(C(C)=O)C2
Biological Activity: GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA2 of 8.41 and a pKi of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases[1].
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GPR84 antagonist 11 | GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA2 of 8.41 and a pKi of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases. | |||||||||||||||||||||
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