31428-61-2
Chemical Structure
Tiamenidine
Synonym(s): HOE 440
- CAS No.: 31428-61-2
- Formula:C8H10ClN3S
- Molecular Weight:215.70
IUPAC Name: N-(2-chloro-4-methylthiophen-3-yl)-4,5-dihydro-1H-imidazol-2-amine
InChIKey: CVWILQHZFWRYPB-UHFFFAOYSA-N
SMILES: CC1=CSC(Cl)=C1NC2=NCCN2
Biological Activity: Tiamenidine (HOE 440) is an orally active α-2 adrenoceptor agonist. Tiamenidine stimulates peripheral α-adrenergic receptors, causing a transient increase in blood pressure, and activates central adrenergic receptors, inhibiting sympathetic nerve activity. Tiamenidine lowers blood pressure in hypertensive rats and inhibits plasma renin activity. Tiamenidine reduces ethanol preference and intake in ethanol-preferring rats. Tiamenidine attenuates Xylazine-induced loss of righting reflex. Tiamenidine can be used in research on hypertension[1][2][3][4].
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Tiamenidine | Tiamenidine (HOE 440) is an orally active α-2 adrenoceptor agonist. Tiamenidine stimulates peripheral α-adrenergic receptors, causing a transient increase in blood pressure, and activates central adrenergic receptors, inhibiting sympathetic nerve activity. Tiamenidine lowers blood pressure in hypertensive rats and inhibits plasma renin activity. Tiamenidine reduces ethanol preference and intake in ethanol-preferring rats. Tiamenidine attenuates Xylazine-induced loss of righting reflex. Tiamenidine can be used in research on hypertension. | |||||||||||||||||||||
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References
- [1]. Opitz K, et al. The effect of clonidine and related substances on voluntary ethanol consumption in rats. Drug and alcohol dependence. 1990 Feb;25(1):43-8.
- [2]. Hansson BG, et al. Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine. British journal of clinical pharmacology. 1981 Jan;11(1):73-7.
- [3]. Colpaert FC. Effects of putative α‐adrenoceptor antagonists and of other compounds on the loss of the righting reflex and on exophthalmia induced by xylazine in the rat. Drug development research. 1986 Feb;7(2):125-40.
- [4]. Colpaert FC. Maximal magnitude of effect and potency of putative α‐adrenoceptor agonists in causing CNS depression, et al. Drug development research. 1986 Mar;7(3):209-20.
