31501-55-0
Chemical Structure
Lonchocarpin
Synonym(s): Lonchocarpine
- CAS No.: 31501-55-0
- Formula:C20H18O3
- Molecular Weight:306.36
IUPAC Name: (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-phenylprop-2-en-1-one
InChIKey: UEXPKLJRGIWQBF-CSKARUKUSA-N
SMILES: O=C(/C=C/C1=CC=CC=C1)C2=CC=C3C(C=CC(C)(O3)C)=C2O
Biological Activity:
Lonchocarpin (Lonchocarpine) is a Wnt/β-catenin signaling pathway inhibitor. The IC50 of Lonchocarpin in SW480 pBAR/Renilla cells is 4 μM. Acting downstream of β-catenin stabilization, Lonchocarpin inhibits β-catenin nuclear localization and TCF-mediated transcription, as well as the proliferation and migration of colorectal cancer cells. Lonchocarpin enhances Nrf2/ARE-mediated antioxidant responses in primary astrocytes via AMPK and JNK-related signaling, reduces H2O2-induced ROS production, and increases the expression of HO-1, NQO1 and MnSOD. Lonchocarpin can be used in research on colorectal cancer and oxidative stress[1][2].
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Lonchocarpin | Lonchocarpin (Lonchocarpine) is a Wnt/β-catenin signaling pathway inhibitor. The IC50 of Lonchocarpin in SW480 pBAR/Renilla cells is 4 μM. Acting downstream of β-catenin stabilization, Lonchocarpin inhibits β-catenin nuclear localization and TCF-mediated transcription, as well as the proliferation and migration of colorectal cancer cells. Lonchocarpin enhances Nrf2/ARE-mediated antioxidant responses in primary astrocytes via AMPK and JNK-related signaling, reduces H2O2-induced ROS production, and increases the expression of HO-1, NQO1 and MnSOD. Lonchocarpin can be used in research on colorectal cancer and oxidative stress. |
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References
- [1]. Jeong YH, et al. Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes. Biomolecules & therapeutics. 2016 Nov 01;24(6):581-588.
- [2]. Predes D, et al. The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation. Cancers. 2019 Dec 07;11(12):1968.
