3153-83-1
Chemical Structure
Spinacetin
- CAS No.: 3153-83-1
- Formula:C17H14O8
- Molecular Weight:346.29
IUPAC Name: 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one
InChIKey: XWIDINOKCRFVHQ-UHFFFAOYSA-N
SMILES: COC1=C(O)C=CC(C2=C(O)C(C3=C(C=C(O)C(OC)=C3O)O2)=O)=C1
Biological Activity: Spinacetin is an orally active flavonoid glycoside found in Inula japonica, with antioxidant and anti-inflammatory activities. Spinacetin inhibits major inflammatory signaling pathways such as Syk, MAPK, and NF-κB, and reduces Ca2+-dependent release of allergic mediators. Spinacetin induces protective autophagy and enhances antioxidant defense by upregulating SIRT3/SIRT1/PGC-1α, activating AMPK, and inhibiting mTOR and NF-κB, thereby exerting anti-apoptotic, cardioprotective, bladder-protective, and hepatoprotective effects. Spinacetin alleviates Doxorubicin (HY-15142A)-induced cardiotoxicity and reduces Cyclophosphamide (HY-17420)-induced hemorrhagic cystitis. Spinacetin can be used in research on allergic reactions, cardiotoxicity, cystitis, and cadmium-aggravated hepatic ischemia[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Spinacetin | 99.98% | Spinacetin is an orally active flavonoid glycoside found in Inula japonica, with antioxidant and anti-inflammatory activities. Spinacetin inhibits major inflammatory signaling pathways such as Syk, MAPK, and NF-κB, and reduces Ca2+-dependent release of allergic mediators. Spinacetin induces protective autophagy and enhances antioxidant defense by upregulating SIRT3/SIRT1/PGC-1α, activating AMPK, and inhibiting mTOR and NF-κB, thereby exerting anti-apoptotic, cardioprotective, bladder-protective, and hepatoprotective effects. Spinacetin alleviates Doxorubicin (HY-15142A)-induced cardiotoxicity and reduces Cyclophosphamide (HY-17420)-induced hemorrhagic cystitis. Spinacetin can be used in research on allergic reactions, cardiotoxicity, cystitis, and cadmium-aggravated hepatic ischemia. | ||||||||||||||||||||
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References
- [1]. Ji N, et al. Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model. Frontiers in pharmacology. 2018;9:824. [Content Brief]
- [2]. Liu D, et al. Spinacetin alleviates doxorubicin-induced cardiotoxicity by initiating protective autophagy through SIRT3/AMPK/mTOR pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul;101:154098.
- [3]. Wróbel J, et al. Plant-Derived Spinacetin Mitigates Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats. International journal of molecular sciences. 2026 Mar 27;27(7):3056. [Content Brief]
- [4]. Bibi A, et al. Therapeutic potential of spinacetin against cadmium-exacerbated hepatic ischemia/reperfusion injury via regulating AMPK/SIRT1/PGC-1α and NF-κB pathway. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2025 Dec;92:127757.
