315705-10-3
315705-10-3
Chemical Structure
GCN2 activator-1
- CAS No.: 315705-10-3
- Formula:C11H10N6S2
- Molecular Weight:290.37
IUPAC Name: 4'-methyl-N2-(pyrimidin-2-yl)-[4,5'-bithiazole]-2,2'-diamine
InChIKey: FHVNBKUGDCJKHS-UHFFFAOYSA-N
SMILES: NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1
Biological Activity: GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD)[1].
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GCN2 activator-1 | 99.69% | GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD). | ||||||||||||||||||||
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