316-05-2
316-05-2
Chemical Structure
Quinacrine methanesulfonate
Synonym(s): Mepacrine methanesulfonate; SN-390 methanesulfonate
- CAS No.: 316-05-2
- Formula:C25H38ClN3O7S2
- Molecular Weight:592.17
IUPAC Name: N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine dimethanesulfonate
InChIKey: BSSDNUXUOKRRHO-UHFFFAOYSA-N
SMILES: CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.CS(=O)(O)=O.CS(=O)(O)=O
Biological Activity: Quinacrine (Mepacrine) methanesulfonate is a potent, orally active antimalarial agent with antitumor effects in vitro and in vivo. Quinacrine dihydrochloride inhibits NF-κB and activates p53 signaling, inducing apoptosis in tumor cells[1][2].
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Quinacrine methanesulfonate | Quinacrine (Mepacrine) methanesulfonate is a potent, orally active antimalarial agent with antitumor effects in vitro and in vivo. Quinacrine dihydrochloride inhibits NF-κB and activates p53 signaling, inducing apoptosis in tumor cells. | |||||||||||||||||||||
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References
- [1]. Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64. [Content Brief]
- [2]. Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46. [Content Brief]
