3167-49-5
Chemical Structure
6-Aminonicotinic acid
- CAS No.: 3167-49-5
- Formula:C6H6N2O2
- Molecular Weight:138.13
IUPAC Name: 6-aminonicotinic acid
InChIKey: ZCIFWRHIEBXBOY-UHFFFAOYSA-N
SMILES: O=C(O)C1=CN=C(N)C=C1
Biological Activity: 6-Aminonicotinic acid is an analog of Niacin (HY-B0143) and also a GABAA receptor agonist with a Ki value of 4.4 μM in rats. 6-Aminonicotinic acid binds to both native and recombinant GABAA receptors, is metabolized into non-functional pyridine nucleotide analogs to inhibit dehydrogenases, and suppresses the proliferation of T2 bacteriophages. 6-Aminonicotinic acid accumulates in specific bacterial cells in the form of pyridine nucleotide analog metabolites. 6-Aminonicotinic acid can be used in research related to neurological disorders such as anxiety, epilepsy and schizophrenia, and also serves as an intermediate in organic synthesis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6-Aminonicotinic acid | 99.56% | 6-Aminonicotinic acid is an analog of Niacin (HY-B0143) and also a GABAA receptor agonist with a Ki value of 4.4 μM in rats. 6-Aminonicotinic acid binds to both native and recombinant GABAA receptors, is metabolized into non-functional pyridine nucleotide analogs to inhibit dehydrogenases, and suppresses the proliferation of T2 bacteriophages. 6-Aminonicotinic acid accumulates in specific bacterial cells in the form of pyridine nucleotide analog metabolites. 6-Aminonicotinic acid can be used in research related to neurological disorders such as anxiety, epilepsy and schizophrenia, and also serves as an intermediate in organic synthesis. | ||||||||||||||||||||
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References
- [1]. Cobb JR, et al. Metabolism of 6-aminonicotinic acid in Escherichia coli. J Bacteriol. 1977 Sep;131(3):789-94.
- [2]. Petersen JG, et al. Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists. European journal of medicinal chemistry. 2014 Sep 12;84:404-16. [Content Brief]
- [3]. Gennaro A, et al. Electrocatalytic synthesis of 6‑aminonicotinic acid at silver cathodes under mild conditions. Electrochemistry Communications, 2004, 6(7): 627‑631.
