31894-34-5
31894-34-5
Chemical Structure
ζ-Stat trisodium
Synonym(s): NSC37044 trisodium
- CAS No.: 31894-34-5
- Formula:C10H5Na3O10S3
- Molecular Weight:450.31
IUPAC Name: sodium 8-hydroxynaphthalene-1,3,6-trisulfonate
InChIKey: VQXXRDCDIFAODW-UHFFFAOYSA-K
SMILES: O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O
Biological Activity: ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].
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ζ-Stat trisodium | 97.0% | ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro. | ||||||||||||||||||||
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References
- [1]. Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. [Content Brief]
- [2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665. [Content Brief]
