321595-13-5
Chemical Structure
Distearoylphosphatidylserine sodium
Synonym(s): DSPS sodium
- CAS No.: 321595-13-5
- Formula:C42H81NNaO10P
- Molecular Weight:814.06
InChIKey: SJRBMGBLPUBGJL-MBAWARMDSA-M
SMILES: O=C(O[Na])[C@@H](N)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)(O)=O
Biological Activity: Distearoylphosphatidylserine (DSPS) sodium is an anionic phospholipid. Distearoylphosphatidylserine sodium possesses both a hydrophilic head group and a hydrophobic tail, enabling it to self-assemble in aqueous phases to form stable lipid bilayer structures. Distearoylphosphatidylserine sodium promotes uptake by phagocytes and participates in the endosomal escape of lipid nanoparticles (LNPs) within cells. Distearoylphosphatidylserine sodium can be used in research on the construction of lipid nanoparticles for targeted delivery of siRNA (for immune or anti-inflammatory therapy), as well as the preparation of ultrasound contrast microbubbles for molecular imaging[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Distearoylphosphatidylserine sodium | 99.99% | Distearoylphosphatidylserine (DSPS) sodium is an anionic phospholipid. Distearoylphosphatidylserine sodium possesses both a hydrophilic head group and a hydrophobic tail, enabling it to self-assemble in aqueous phases to form stable lipid bilayer structures. Distearoylphosphatidylserine sodium promotes uptake by phagocytes and participates in the endosomal escape of lipid nanoparticles (LNPs) within cells. Distearoylphosphatidylserine sodium can be used in research on the construction of lipid nanoparticles for targeted delivery of siRNA (for immune or anti-inflammatory therapy), as well as the preparation of ultrasound contrast microbubbles for molecular imaging. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Leong-Poi H, et al. Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapy. Cardiovascular research. 2009 Nov 01;84(2):190-200.
- [2]. Bressy C, et al. Inhibition of c-Rel expression in myeloid and lymphoid cells with distearoyl -phosphatidylserine (DSPS) liposomal nanoparticles encapsulating therapeutic siRNA. PloS one. 2022;17(12):e0276905.
- [3]. Nadler M, et al. Following the structural changes during zinc-induced crystallization of charged membranes using time-resolved solution X-ray scattering. Soft Matter. 2011;7:1512.
