324758-66-9
324758-66-9
Chemical Structure
Sabiporide hydrochloride
Synonym(s): BIIB 722 hydrochloride
- CAS No.: 324758-66-9
- Formula:C18H20ClF3N6O2
- Molecular Weight:444.84
IUPAC Name: 4-(4-(1H-pyrrole-2-carbonyl)piperazin-1-yl)-N-carbamimidoyl-3-(trifluoromethyl)benzamide hydrochloride
InChIKey: UFVMVHAWZDUFMJ-UHFFFAOYSA-N
SMILES: O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CN3)=O)CC2)C(C(F)(F)F)=C1.[H]Cl
Biological Activity: Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death[1][2].
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Sabiporide hydrochloride | Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death. | |||||||||||||||||||||
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References
- [1]. Touret N, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003 Jan 17;459(2-3):151-8. [Content Brief]
- [2]. Park HS, et al. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005 Nov 2;1061(1):67-71. [Content Brief]
