32476-67-8
32476-67-8
Chemical Structure
Periplocymarin
- CAS No.: 32476-67-8
- Formula:C30H46O8
- Molecular Weight:534.68
IUPAC Name: 4-((3S,5S,8R,9S,10R,13R,14S,17R)-5,14-dihydroxy-3-(((2R,4S,5R,6R)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
InChIKey: XRWQBDJPMXRDOQ-YUUDFPFBSA-N
SMILES: O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C4=CC(OC4)=O)CC2)C)([H])[C@@]5([C@@](O)(C[C@@H](O[C@@]6([H])C[C@@H]([C@H](O)[C@@H](C)O6)OC)CC5)CC3)C
Biological Activity: Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Periplocymarin | 99.90% | Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cymarin | 97.28% | Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant. |
||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uzarigenin digitaloside | Uzarigenin digitaloside is a Steroids product that can be isolated from the herbs of Nerium oleander. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Helveticoside | 95.99% | Helveticoside (Strophanthidin-digitoxoside) is a helveticosid, possesses an ED50 of 0.17 μM for isolated guinea-pig ileum. Helveticoside has anticancer effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Periplocin (Standard) | ≥98% | Periplocin (Standard) is the analytical standard of Periplocin. This product is intended for research and analytical applications. Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Odoroside | Odoroside (Solanoside) is a cardiac glycoside present in oleander (Nerium oleander L). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
8-Hydroxyodoroside A | 8-Hydroxyodoroside A is a Steroids product that can be isolated from the herbs of Nerium indicum. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] | Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] is a cardenolide isolated from the root barks of Periploca sepium. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Odoroside A | 99.73% | Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Neriifolin | 99.70% | Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[2. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sarmentocymarin | Sarmentocymarin can be isolated from the air-dried powd. roots of Cryptolepis buchanani Roem. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Martey ON, et al. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014 May;35(4):195-206. [Content Brief]
- [2]. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfidebond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017 Nov;24(1):1170-1178. [Content Brief]
