324777-01-7
Chemical Structure
ALDH3A1-IN-4
- CAS No.: 324777-01-7
- Formula:C14H11FN2O2S
- Molecular Weight:290.31
IUPAC Name: 1-((4-fluorophenyl)sulfonyl)-2-methyl-1H-benzo[d]imidazole
InChIKey: SMGZHCSEIBBFEJ-UHFFFAOYSA-N
SMILES: O=S(=O)(C1=CC=C(F)C=C1)N2C=3C=CC=CC3N=C2C
Biological Activity: ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ALDH3A1-IN-4 | 99.91% | ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma. | ||||||||||||||||||||
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