32507-77-0
Chemical Structure
Ergosta-7,22-dien-3-one
- CAS No.: 32507-77-0
- Formula:C28H44O
- Molecular Weight:396.65
IUPAC Name: (9R,10S,13R,14R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-1,2,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: AHWOEMBXZXGDBQ-MERCMEHUSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(C)C)([H])C3=CCC(CC(CC4)=O)[C@@]4(C)[C@@]3([H])CC1
Biological Activity: Ergosta-7,22-dien-3-on is a lanosterane isolated from the fruiting bodies of Ganoderma lucidum. ent-16-Kaurene-3b,15b,18-triol inhibits platelet aggregation[1][2]. Ergosta-7,22-dien-3-on is able to stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in vitro[3].
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Ergosta-7,22-dien-3-one | 96% | Ergosta-7,22-dien-3-on is a lanosterane isolated from the fruiting bodies of Ganoderma lucidum. ent-16-Kaurene-3b,15b,18-triol inhibits platelet aggregation. Ergosta-7,22-dien-3-on is able to stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in vitro. | ||||||||||||||||||||
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References
- [1]. Lu W, et al. Platelet aggregation potentiators from cho-rei. Chem Pharm Bull (Tokyo). 1985 Nov;33(11):5083-7. [Content Brief]
- [2]. Lin C N, Tome W P, Won S J. A lanostanoid of formosan Ganoderma lucidum[J]. Phytochemistry, 1990, 29(2): 673-675.
- [3]. Ramos-Ligonio A, López-Monteon A, Lagunes-Castro MS, et al. In Vitro Expression of Toll-Like Receptors and Proinflammatory Molecules Induced by Ergosta- 7,22-Dien-3-One Isolated from a Wild Mexican Strain of Ganoderma oerstedii (Agaricomycetes). Int J Med Mushrooms. 2017;19(3):203-211. [Content Brief]
