32597-86-7
Chemical Structure
(E/Z)-Icerguastat hydrochloride
Synonym(s): (E/Z)-Sephin1 hydrochloride; (E/Z)-IFB-088 hydrochloride
- CAS No.: 32597-86-7
- Formula:C8H10Cl2N4
- Molecular Weight:233.10
IUPAC Name: (E)-2-(2-chlorobenzylidene)hydrazine-1-carboximidamide hydrochloride
InChIKey: JVYSPIAJJZIYGP-NKPNRJPBSA-N
SMILES: ClC1=CC=CC=C1/C=N/NC(N)=N.Cl
Biological Activity: (E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains[1].
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(E/Z)-Icerguastat hydrochloride | (E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains. | |||||||||||||||||||||
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