327026-93-7
327026-93-7
Chemical Structure
Lensiprazine
- CAS No.: 327026-93-7
- Formula:C24H27FN4O2
- Molecular Weight:422.50
IUPAC Name: (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazin-1-yl)-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one
InChIKey: SDAMYSWGWHXMRT-MRXNPFEDSA-N
SMILES: C[C@H]1OC2=C(N3CCN(CC3)CCCC(C4=C5)=CNC4=CC=C5F)C=CC=C2NC1=O
Biological Activity: Lensiprazine is a potent dopamine D2 receptor (D2R) antagonist that acts as a serotonin reuptake inhibitor. Lensiprazine can be used to study bipolar disorder and schizophrenia[1][2][3].
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Lensiprazine | Lensiprazine is a potent dopamine D2 receptor (D2R) antagonist that acts as a serotonin reuptake inhibitor. Lensiprazine can be used to study bipolar disorder and schizophrenia. | |||||||||||||||||||||
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References
- [1]. Bollu R, et al. Potential anti-proliferative agents from 1, 4-benzoxazinone-quinazolin-4 (3H)-one templates[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27(24): 5481-5484. [Content Brief]
- [2]. Lange J H M, et al. Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs[J]. Journal of medicinal chemistry, 2007, 50(21): 5103-5108. [Content Brief]
- [3]. Rauly-Lestienne I, et al. Differential profile of typical, atypical and third generation antipsychotics at human 5-HT 7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties[J]. Naunyn-Schmiedeberg's archives of pharmacology, 2007, 376: 93-105. [Content Brief]
