32747-07-2
Chemical Structure
Taurohyocholic acid
Synonym(s): THCA
- CAS No.: 32747-07-2
- Formula:C26H45NO7S
- Molecular Weight:515.70
IUPAC Name: 2-((R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid
InChIKey: XSOLDPYUICCHJX-QZEPYOAJSA-N
SMILES: O[C@@H]1CC[C@]2([C@@]([H])(C1)[C@H]([C@H]([C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@@]4([C@@H](CCC(NCCS(O)(=O)=O)=O)C)[H])[H])C)[H])[H])O)O)C
Biological Activity: Taurohyocholic acid is a taurine-conjugated hyocholic acid. Taurohyocholic acid is predictor of the efficacy of tyrosine kinase inhibitors combined withPD-1 inhibitors in hepatocellular carcinoma (HCC)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Taurohyocholic acid | 99.89% | Taurohyocholic acid is a taurine-conjugated hyocholic acid. Taurohyocholic acid is predictor of the efficacy of tyrosine kinase inhibitors combined withPD-1 inhibitors in hepatocellular carcinoma (HCC). | ||||||||||||||||||||
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Taurohyocholic acid-d4 sodium | Taurohyocholic acid-d4 (sodium) is the deuterium labeled Taurohyocholic acid sodium. | |||||||||||||||||||||
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References
- [1]. He J, et al. Semi-Preparative Isolation and Purification of Three Tauro-Conjugated Cholic Acids from Pulvis Fellis Suis by HSCCC Coupled with ELSD Detection. Chromatographia. 2011;73(3-4):361-365. [Content Brief]
- [2]. Chen Y, et al. Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma. Front Pharmacol. 2024 Feb 23;15:1364924. [Content Brief]
