329906-08-3
329906-08-3
Chemical Structure
F0161-0219
- CAS No.: 329906-08-3
- Formula:C31H21N3O2S
- Molecular Weight:499.58
InChIKey: UFZKPNGFOGKDIO-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C=CC=CC2=C1)NC3=NC(C4=CC=CC(NC(C5=CC=C6C=CC=CC6=C5)=O)=C4)=CS3
Biological Activity: F0161-0219 is an ABCG2 inhibitor with a Kd value of 45.4 μM. F0161-0219 binds within the substrate transport channel, blocks efflux function, stabilizes the transporter, and retains Doxorubicin in the central cavity. F0161-0219 restores cellular sensitivity to Doxorubicin and increases the intracellular accumulation of multiple ABCG2 substrates. F0161-0219 can be used for research on breast cancer[1].
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F0161-0219 | F0161-0219 is an ABCG2 inhibitor with a Kd value of 45.4 μM. F0161-0219 binds within the substrate transport channel, blocks efflux function, stabilizes the transporter, and retains Doxorubicin in the central cavity. F0161-0219 restores cellular sensitivity to Doxorubicin and increases the intracellular accumulation of multiple ABCG2 substrates. F0161-0219 can be used for research on breast cancer. | |||||||||||||||||||||
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