33008-99-0
Chemical Structure
5'-Phosphoguanylyl-(3',5')-guanosine
Synonym(s): pGpG
- CAS No.: 33008-99-0
- Formula:C20H26N10O15P2
- Molecular Weight:708.43
IUPAC Name: ((2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChIKey: ZEHOHLFQOXAZHX-MHARETSRSA-N
SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(O)(O[C@H]4[C@@H](O)[C@H](N(C=N5)C6=C5C(N=C(N)N6)=O)O[C@@H]4COP(O)(O)=O)=O)O3)C=N2)NC(N)=N1
Biological Activity: 5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5'-Phosphoguanylyl-(3',5')-guanosine | 96.96% | 5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids. | ||||||||||||||||||||
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References
- [1]. Nesbitt NM, et, al. Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate. Biotechnol Rep (Amst). 2015 May 5;7:30-37. [Content Brief]
- [2]. Cohen D, et, al. Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11359-64. [Content Brief]
