332179-76-7
Chemical Structure
RGD-4C
- CAS No.: 332179-76-7
- Formula:C42H60N14O16S4
- Molecular Weight:1145.27
InChIKey: DXIKEERYADAVLF-CFFDDJBSSA-N
SMILES: O=C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(O)=O)=O)NC([C@@H](N)C)=O)C(NCC(O)=O)=O)[C@@H](NC([C@@](CSSC[C@](C(N[C@H]2CCCNC(N)=N)=O)([H])NC1=O)([H])NC([C@@H](NC(CNC2=O)=O)CC(O)=O)=O)=O)CC3=CC=CC=C3
Biological Activity: RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3].
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RGD-4C | 99.91% | RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models. | ||||||||||||||||||||
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References
- [1]. Assa-Munt N, et al. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry. 2001 Feb 27;40(8):2373-8. [Content Brief]
- [2]. Yin R, et al. Effect of RGD-4C position is more important than disulfide bonds on antiangiogenic activity of RGD-4C modified endostatin derived synthetic polypeptide. Bioconjug Chem. 2010 Jul 21;21(7):1142-7. [Content Brief]
- [3]. Zuppone S, et al. A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer. Front Oncol. 2022 Apr 11;12:846958. [Content Brief]
