33275-72-8
Chemical Structure
ME67
Synonym(s): EM-B enol ether
- CAS No.: 33275-72-8
- Formula:C37H65NO11
- Molecular Weight:699.91
InChIKey: RVWZXQUMKFWVJM-JJRNAJBXSA-N
SMILES: C[C@]1(OC([C@@H]([C@H]([C@H]([C@H](OC([C@@H]([C@H]([C@@H]2C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)=O)CC)C)O)C)=C(C1)C)[C@@H]2O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O
Biological Activity: ME67 (EM-B enol ether) is a motilin receptor (Motilin Receptor) agonist with pIC50 values of 8.38 and 6.49 for rabbit and human motilin receptors, respectively. ME67 activates the G protein-coupled Motilin Receptor, inducing calcium mobilization, calcium flux, receptor internalization, and gastrointestinal motility. ME67 can be used in research on gastrointestinal motility disorders[1][2].
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ME67 | ME67 (EM-B enol ether) is a motilin receptor (Motilin Receptor) agonist with pIC50 values of 8.38 and 6.49 for rabbit and human motilin receptors, respectively. ME67 activates the G protein-coupled Motilin Receptor, inducing calcium mobilization, calcium flux, receptor internalization, and gastrointestinal motility. ME67 can be used in research on gastrointestinal motility disorders. | |||||||||||||||||||||
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References
- [1]. Thielemans L, et al. The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochemical and biophysical research communications. 2002 May 17;293(4):1223-7. [Content Brief]
- [2]. Thielemans L, et al. Desensitization of the human motilin receptor by motilides. The Journal of pharmacology and experimental therapeutics. 2005 Jun;313(3):1397-405. [Content Brief]
