332926-04-2
332926-04-2
Chemical Structure
PF-00277343
- CAS No.: 332926-04-2
- Formula:C24H20FN3O4
- Molecular Weight:433.43
IUPAC Name: 2-(4-(3-(4-fluorobenzyl)-4-hydroxyphenoxy)-3,5-dimethylphenyl)-1,2,4-triazine-3,5(2H,4H)-dione
InChIKey: HQXKNHQWCAXRDN-UHFFFAOYSA-N
SMILES: O=C(N(N=C1)C2=CC(C)=C(C(C)=C2)OC3=CC=C(C(CC4=CC=C(C=C4)F)=C3)O)NC1=O
Biological Activity: PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models[1].
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PF-00277343 | PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models. | |||||||||||||||||||||
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