333311-00-5
Chemical Structure
G6PD-IN-2
- CAS No.: 333311-00-5
- Formula:C18H17NO3S
- Molecular Weight:327.40
IUPAC Name: N-(4-hydroxynaphthalen-1-yl)-2,5-dimethylbenzenesulfonamide
InChIKey: SEBVJYWOFMIHFC-UHFFFAOYSA-N
SMILES: O=S(=O)(NC1=CC=C(O)C=2C=CC=CC12)C3=CC(=CC=C3C)C
Biological Activity: G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) with an IC50 value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria[1].
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G6PD-IN-2 | G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) with an IC50 value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria. | |||||||||||||||||||||
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