333963-42-1
Chemical Structure
Cobiprostone
Synonym(s): SPI 8811
- CAS No.: 333963-42-1
- Formula:C21H34F2O5
- Molecular Weight:404.49
IUPAC Name: 7-((2R,4aR,5R,7aR)-2-((S)-1,1-difluoro-3-methylpentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic acid
InChIKey: SDDSJMXGJNWMJY-BRHAQHMBSA-N
SMILES: O=C(O)CCCCCC[C@H]([C@]1([H])[C@]2([H])O[C@@](O)(C(F)(F)C[C@@H](C)CC)CC1)C(C2)=O
Biological Activity: Cobiprostone (SPI 8811) is a type-2 chloride channel activator. Cobiprostone protects against Indomethacin (HY-14397)-induced depolarization of mitochondrial membrane potential and reverses the loss of mitochondrial membrane potential. Cobiprostone protects against NSAID-induced cellular damage[1].
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Cobiprostone | Cobiprostone (SPI 8811) is a type-2 chloride channel activator. Cobiprostone protects against Indomethacin (HY-14397)-induced depolarization of mitochondrial membrane potential and reverses the loss of mitochondrial membrane potential. Cobiprostone protects against NSAID-induced cellular damage. | |||||||||||||||||||||
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