335275-62-2
Chemical Structure
N-Acetylmannosamine 6-phosphate sodium salt
Synonym(s): ManNAc-6P sodium salt
- CAS No.: 335275-62-2
- Formula:C8H15NNaO9P
- Molecular Weight:323.17
InChIKey: BHRLHHLDCICKHI-XNJRRJNCSA-M
SMILES: O=P(O)(O[Na])OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C=O)NC(C)=O
Biological Activity: N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Acetylmannosamine 6-phosphate sodium salt | 99.89% | N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy. | ||||||||||||||||||||
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References
- [1]. Olson ME, et al. Sialic acid catabolism in Staphylococcus aureus. J Bacteriol. 2013;195(8):1779-1788. [Content Brief]
- [2]. Pertusati F, et al. Synthesis of 2-Acetamido-1,3,4-Tri-O-Acetyl-2-Deoxy-D-Mannopyranose -6-Phosphate Prodrugs as Potential Therapeutic Agents. Curr Protoc. 2022;2(8):e500. [Content Brief]
