335401-44-0
335401-44-0
Chemical Structure
BDW568
- CAS No.: 335401-44-0
- Formula:C12H12N4O2S2
- Molecular Weight:308.38
InChIKey: RNNRGNUAQCUYEG-UHFFFAOYSA-N
SMILES: COC(CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3)=O
Biological Activity: BDW568 is a selective STINGA230 agonist with an EC50 of 5.7 μM. BDW568 triggers the interferon signaling pathway and induces the expression of interferon-stimulated genes including MX1 and OAS1. BDW568 is applicable for cancer-related research[1][2][3].
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BDW568 | 99.4% | BDW568 is a selective STINGA230 agonist with an EC50 of 5.7 μM. BDW568 triggers the interferon signaling pathway and induces the expression of interferon-stimulated genes including MX1 and OAS1. BDW568 is applicable for cancer-related research. | ||||||||||||||||||||
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References
- [1]. Ling X, et al. Innovative CRISPR Screening Promotes Drug Target Identification. ACS Cent Sci. 2022 Nov 23;8(11):1477-1479. [Content Brief]
- [2]. Tang Z, et al. Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies. ACS Med Chem Lett. 2024;15(5):653-658. Published 2024 Apr 12. [Content Brief]
- [3]. Tang Z, et al. Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants. bioRxiv [Preprint]. 2023 Jul 10:2023.07.02.547363. [Content Brief]
