336115-72-1
336115-72-1
Chemical Structure
CK0106023
- CAS No.: 336115-72-1
- Formula:C30H32BrClN4O2
- Molecular Weight:595.96
IUPAC Name: N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide
InChIKey: PZVLDHUUSWUATQ-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=CC=C2)C(C(CC)N(CCCN(C)C)C(C(C=C3)=CC=C3Br)=O)=NC4=C1C=CC(Cl)=C4
Biological Activity: CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice[1][2].
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CK0106023 | CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice. | |||||||||||||||||||||
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