3423-07-2
Chemical Structure
N-Methylcoclaurine
- CAS No.: 3423-07-2
- Formula:C18H21NO3
- Molecular Weight:299.36
InChIKey: BOKVLBSSPUTWLV-INIZCTEOSA-N
SMILES: OC1=CC2=C(C=C1OC)CCN(C)[C@H]2CC3=CC=C(O)C=C3
Biological Activity: N-Methylcoclaurine is an orally active anticancer agent and PDI inhibitor with an IC50 of 3.91 μM for the bovine-derived target. N-Methylcoclaurine selectively binds to κ opioid receptors with a Ki value of 0.9 μM. N-Methylcoclaurine inhibits tumor cell proliferation, migration, and invasion, and suppresses tumor growth in vivo. N-Methylcoclaurine inhibits iNOS expression and scavenges NO and DPPH radicals. N-Methylcoclaurine is a substrate of CyNMCH and an important branch intermediate in the biosynthesis of benzylisoquinoline alkaloids. N-Methylcoclaurine can be used in research related to hepatocellular carcinoma and neurological diseases[1].
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N-Methylcoclaurine | N-Methylcoclaurine is an orally active anticancer agent and PDI inhibitor with an IC50 of 3.91 μM for the bovine-derived target. N-Methylcoclaurine selectively binds to κ opioid receptors with a Ki value of 0.9 μM. N-Methylcoclaurine inhibits tumor cell proliferation, migration, and invasion, and suppresses tumor growth in vivo. N-Methylcoclaurine inhibits iNOS expression and scavenges NO and DPPH radicals. N-Methylcoclaurine is a substrate of CyNMCH and an important branch intermediate in the biosynthesis of benzylisoquinoline alkaloids. N-Methylcoclaurine can be used in research related to hepatocellular carcinoma and neurological diseases. | |||||||||||||||||||||
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