342416-30-2
342416-30-2
Chemical Structure
IRES-C11
- CAS No.: 342416-30-2
- Formula:C13H11Cl2NO4
- Molecular Weight:316.14
IUPAC Name: 3,4-dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione
InChIKey: SYBFPEVCOHEALP-UHFFFAOYSA-N
SMILES: O=C(C(Cl)=C1Cl)N(CC2=CC=C(OC)C=C2OC)C1=O
Biological Activity: IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IRES-C11 | 98.01% | IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes. | ||||||||||||||||||||
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References
- [1]. Brent Holmes, et al. Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma. J Biol Chem. 2016 Jul 1;291(27):14146-14159. [Content Brief]
- [2]. Y Shi, et al. Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress. Oncogene. 2016 Feb 25;35(8):1015-24. [Content Brief]
