342790-23-2
Chemical Structure
Hepcidin-20 (human)
- CAS No.: 342790-23-2
- Formula:C85H135N27O23S9
- Molecular Weight:2191.73
InChIKey: KCGSCDOCNSLUQM-BJMJBLFRSA-N
SMILES: O=C(N[C@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CO)=O)CCCNC(N)=N)[C@@H](NC([C@@](CSSC[C@](C(NCC(N[C@H]2CCSC)=O)=O)([H])NC1=O)([H])NC([C@](NC(CNC([C@@](CSSC[C@](C(N3)=O)([H])NC2=O)([H])NC([C@@](CSSC[C@H]3C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)([H])NC4=O)=O)=O)=O)([H])CSSC[C@@H](C(N[C@@](C(N[C@H]4CC5=CC=CC=C5)=O)([H])[C@@H](C)CC)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)CC6=CN=CN6
Biological Activity: Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains[1][2][3].
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Hepcidin-20 (human) | Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains. | |||||||||||||||||||||
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References
- [1]. Maisetta G, et al. pH-dependent disruption of Escherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. 2013 Jun;280(12):2842-54. [Content Brief]
- [2]. Del Gaudio G, et al. Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid. Antimicrob Agents Chemother. 2013 Sep;57(9):4314-4321. [Content Brief]
- [3]. Brancatisano FL, et al. Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling. 2014;30(4):435-46. [Content Brief]
