342795-11-3
342795-11-3
Chemical Structure
Namoline
- CAS No.: 342795-11-3
- Formula:C10H3ClF3NO4
- Molecular Weight:293.58
IUPAC Name: 3-chloro-6-nitro-2-(trifluoromethyl)-4H-chromen-4-one
InChIKey: DYEGRZKBJMKSKD-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(C(F)(F)F)OC2=CC=C([N+]([O-])=O)C=C12
Biological Activity: Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1].
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Namoline | Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research. | |||||||||||||||||||||
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