343250-05-5
Chemical Structure
CP-94707
- CAS No.: 343250-05-5
- Formula:C21H16N4OS
- Molecular Weight:372.44
IUPAC Name: 3-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)benzyl)benzo[d]thiazol-2(3H)-one
InChIKey: WUOLYUKMMRCXGH-UHFFFAOYSA-N
SMILES: O=C1SC2=CC=CC=C2N1CC3=CC=C(N4C(C)=NC5=C4C=CN=C5)C=C3
Biological Activity: CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC50 of 4 μM against wild-type and HIV-1 reverse transcriptase Y181I-Y188L double mutant enzymes, and an IC50 of 10 μM against HIV-1 reverse transcriptase K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNALys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection[1].
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CP-94707 | CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC50 of 4 μM against wild-type and HIV-1 reverse transcriptase Y181I-Y188L double mutant enzymes, and an IC50 of 10 μM against HIV-1 reverse transcriptase K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNALys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection. | |||||||||||||||||||||
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References
- [1]. Pata JD, et al. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jul 20;101(29):10548-53. [Content Brief]
