343630-41-1
343630-41-1
Chemical Structure
NS3623
- CAS No.: 343630-41-1
- Formula:C15H10BrF3N6O
- Molecular Weight:427.18
IUPAC Name: 1-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChIKey: JXPULDIATMTIIN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3
Biological Activity: NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NS3623 | 99.0% | NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. | ||||||||||||||||||||
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NS3623 (Standard) | ≥98% | NS3623 (Standard) is the analytical standard of NS3623 (HY-108586). This product is intended for research and analytical applications. NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. | ||||||||||||||||||||
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References
- [1]. Hansen RS, et al. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41. [Content Brief]
- [2]. Diness JG, et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009 Jan;6(1):100-6. [Content Brief]
- [3]. Calloe K, et al. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46. [Content Brief]
