343935-48-8
343935-48-8
Chemical Structure
Sulcardine hydrochloride
- CAS No.: 343935-48-8
- Formula:C24H35Cl2N3O4S
- Molecular Weight:532.52
InChIKey: SYFJLUOYNDUKDP-UHFFFAOYSA-N
SMILES: O=S(NCC1=CC(CN2CCCC2)=C(O)C(CN3CCCC3)=C1)(C4=CC=C(C=C4)OC)=O.Cl.Cl
Biological Activity: Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects[1][2].
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Sulcardine hydrochloride | Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects. | |||||||||||||||||||||
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References
- [1]. Bai DL,et al. Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012 Sep;33(9):1176-86. [Content Brief]
- [2]. Chen W, et al. Characteristics of hERG and hNav1.5 channel blockade by sulcardine sulfate, a novel anti-arrhythmic compound. Eur J Pharmacol. 2019 Feb 5;844:130-138. [Content Brief]
