345989-24-4
345989-24-4
Chemical Structure
MIND4-17
- CAS No.: 345989-24-4
- Formula:C20H15N5O3S
- Molecular Weight:405.43
IUPAC Name: 5-nitro-2-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)pyridine
InChIKey: OZUBDKIROJPQGE-UHFFFAOYSA-N
SMILES: O=[N+](C1=CN=C(C=C1)SC2=NN=C(COC3=CC=CC=C3)N2C4=CC=CC=C4)[O-]
Biological Activity: MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity[1][2].
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MIND4-17 | 99.05% | MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity. | ||||||||||||||||||||
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MIND4 | MIND4 is a neuroprotective thiozoline compound that inhibits the deacetylase SIRT2. MIND4 is also an inducer and activator of the nuclear factor NRF2. MIND4 can induce NRF2 activation in neurons and non-neuronal cells and reduce the production of reactive oxygen and nitrogen intermediates. | |||||||||||||||||||||
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A2ti-1 | 99.78% | A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection. | ||||||||||||||||||||
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A2ti-2 | 99.80% | A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection. | ||||||||||||||||||||
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MIND4-19 | 99.93% | MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease. | ||||||||||||||||||||
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HIV-1 inhibitor-46 | HIV-1 inhibitor-46 (compound 13d) is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor with an EC50 value of 1.425 μM. HIV-1 inhibitor-46 can be used for the research of AIDS. | |||||||||||||||||||||
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NMS-873 | 99.92% | NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. | ||||||||||||||||||||
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MePT-S-N-Pme | MePT-S-N-Pme is an inhibitor of SARS-CoV-2 RdRp activity. MePT-S-N-Pme demonstrates a significant reduced reporter activity with an IC50 of 7 μM in HEK 293 cells. MePT-S-N-Pme has a slight inhibitory effect on nucleotidyltransferase activity. MePT-S-N-Pme significantly inhibits SARS-CoV-2 replication in vitro. | |||||||||||||||||||||
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Insecticidal agent 30 | Insecticidal agent 30 is an orally active insecticidal agent. Insecticidal agent 30 induces rapid contact mortality in adult Brassicogethes aeneus, achieves 100% 24-hour contact mortality against Brassicogethes aeneus, and exhibits moderate insecticidal activity against Drosophila melanogaster. Insecticidal agent 30 can be used for the research of pollen beetle (brassicogethes aeneus) infestation. | |||||||||||||||||||||
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IGF-1R modulator 1 | IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB). IGF-1R modulator 1 can be used for research of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease. | |||||||||||||||||||||
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Mesalazine impurity 6 | Mesalazine impurity 6 is an impurity of Mesalazine. | |||||||||||||||||||||
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References
- [1]. Luisa Quinti, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chem Biol. 2016 Jul 21;23(7):849-861. [Content Brief]
- [2]. Nan Chen, et al. The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury. J Cell Physiol. 2020 Oct;235(10):7204-7213. [Content Brief]
