347406-26-2
347406-26-2
Chemical Structure
Parameritannin A-1
- CAS No.: 347406-26-2
- Formula:C60H48O24
- Molecular Weight:1153.01
SMILES: O[C@H]1[C@]2(C3=CC(O)=C(C=C3)O)OC4=C(C5=C([C@H](C6=C7C(C[C@H]([C@@H](C8=CC(O)=C(C=C8)O)O7)O)=C(C=C6O)O)[C@H]([C@@H](C9=CC(O)=C(C=C9)O)O5)O)C(O)=C4[C@H]%10C%11=C(O)C=C(O)C=C%11O[C@H](C%12=CC(O)=C(C=C%12)O)[C@@H]%10O)[C@@]1([H])C%13=C(O)C=C(O)C=C%13O2
Biological Activity: Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A2 (PLA2)[1][2][3].
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Parameritannin A-1 | Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A2 (PLA2). | |||||||||||||||||||||
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References
- [1]. Kamiya K, et al. Studies on the constituents of bark of Parameria laevigata Moldenke. Chem Pharm Bull (Tokyo). 2001 May;49(5):551-7. [Content Brief]
- [2]. Killday KB, et al. Bioactive A-type proanthocyanidins from Cinnamomum cassia. J Nat Prod. 2011 Sep 23;74(9):1833-41. [Content Brief]
- [3]. Lambert JD, et al. Inhibition of secreted phospholipase A2 by proanthocyanidins: a comparative enzymological and in silico modeling study. J Agric Food Chem. 2012 Aug 1;60(30):7417-20. [Content Brief]
