34787-28-5
Chemical Structure
Ferrichrome Iron-free
Synonym(s): Desferrichrome; DFC; N-Desferriferrichrome
- CAS No.: 34787-28-5
- Formula:C27H45N9O12
- Molecular Weight:687.70
IUPAC Name: N,N',N''-(((2S,5S,8S)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexaazacyclooctadecane-2,5,8-triyl)tris(propane-3,1-diyl))tris(N-hydroxyacetamide)
InChIKey: ZFDAUYPBCXMSBF-ACRUOGEOSA-N
SMILES: CC(N(CCC[C@@H](C(N[C@@H](CCCN(C(C)=O)O)C(NCC(NCC(NCC(N[C@H]1CCCN(C(C)=O)O)=O)=O)=O)=O)=O)NC1=O)O)=O
Biological Activity: Ferrichrome Iron-free (Desferrichrome; DFC; N-Desferriferrichrome) is the ligand form of iron-loaded Ferrichrome when it is not bound to Fe3+. Ferrichrome Iron-free induces apoptosis in gastric cancer cells by activating the JNK-DDIT3 apoptotic axis. As an iron chelator, Ferrichrome Iron-free enables dual-modal imaging of HER2 via conjugation with SiR and Trastuzumab (HY-P9907). Ferrichrome Iron-free can be used in the research of gastric cancer and HER2-overexpressing cancers[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ferrichrome Iron-free | 98.5% | Ferrichrome Iron-free (Desferrichrome; DFC; N-Desferriferrichrome) is the ligand form of iron-loaded Ferrichrome when it is not bound to Fe3+. Ferrichrome Iron-free induces apoptosis in gastric cancer cells by activating the JNK-DDIT3 apoptotic axis. As an iron chelator, Ferrichrome Iron-free enables dual-modal imaging of HER2 via conjugation with SiR and Trastuzumab (HY-P9907). Ferrichrome Iron-free can be used in the research of gastric cancer and HER2-overexpressing cancers. | ||||||||||||||||||||
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References
- [1]. Ijiri M, et al. Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2017 Jun;39(6):1010428317711311. [Content Brief]
- [2]. Ahn SH, et al. Linear Desferrichrome-Linked Silicon-Rhodamine Antibody Conjugate Enables Targeted Multimodal Imaging of HER2 in Vitro and in Vivo. Molecular pharmaceutics. 2019 Mar 04;16(3):1412-1420. [Content Brief]
