35109-88-7
Chemical Structure
2-Iodoadenosine
- CAS No.: 35109-88-7
- Formula:C10H12IN5O4
- Molecular Weight:393.14
IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-2-iodo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: MGEBVSZZNFOIRB-UUOKFMHZSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(I)N=C3N)O[C@@H]1CO
Biological Activity: 2-Iodoadenosine is an activator of the A2A receptor (A2AR), with a human target EC50 of 5.4 µM. 2-Iodoadenosine stimulates cAMP production through adenosine A2A receptors. 2-Iodoadenosine inhibits Forskolin (HY-1537)-stimulated cAMP production through adenosine A3 receptors. 2-Iodoadenosine exhibits competitive inhibition of GI-nucleoside hydrolase relative to guanosine, with a Km/Ki of 61. Research related to central nervous system diseases, cancer, and cardiovascular diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Iodoadenosine | 98.0% | 2-Iodoadenosine is an activator of the A2A receptor (A2AR), with a human target EC50 of 5.4 µM. 2-Iodoadenosine stimulates cAMP production through adenosine A2A receptors. 2-Iodoadenosine inhibits Forskolin (HY-1537)-stimulated cAMP production through adenosine A3 receptors. 2-Iodoadenosine exhibits competitive inhibition of GI-nucleoside hydrolase relative to guanosine, with a Km/Ki of 61. Research related to central nervous system diseases, cancer, and cardiovascular diseases. | ||||||||||||||||||||
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References
- [1]. Estupiñán B, et al. Guanosine-inosine-preferring nucleoside N-glycohydrolase from Crithidia fasciculata. The Journal of biological chemistry. 1994 Sep 16;269(37):23068-73.
- [2]. van Tilburg EW, et al. 2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor. Journal of medicinal chemistry. 2002 Jan 17;45(2):420-9. [Content Brief]
