352220-15-6
352220-15-6
Chemical Structure
(±) Anabasine hydrochloride
- CAS No.: 352220-15-6
- Formula:C10H15ClN2
- Molecular Weight:198.69
IUPAC Name: 3-(piperidin-2-yl)pyridine hydrochloride
InChIKey: VTMZQNZVYCJLGG-UHFFFAOYSA-N
SMILES: C1(C2NCCCC2)=CN=CC=C1.Cl
Biological Activity: (±) Anabasine hydrochloride is the racemic form of Anabasine (HY-B1532). (±) Anabasine hydrochloride stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine hydrochloride inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine hydrochloride is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities[1][2].
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(±) Anabasine hydrochloride | (±) Anabasine hydrochloride is the racemic form of Anabasine (HY-B1532). (±) Anabasine hydrochloride stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine hydrochloride inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine hydrochloride is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities. | |||||||||||||||||||||
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References
- [1]. Zhang YX, et al. Nicotine improves DSS-induced colitis by inhibiting NLRP3 and altering gut microbiota. J Asian Nat Prod Res. 2024 May;26(5):616-635. [Content Brief]
- [2]. Ayers JT, et al. A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine. AAPS J. 2005 Oct 31;7(3):E752-8. [Content Brief]
