35225-13-9
Chemical Structure
Rifamycin AF-013
- CAS No.: 35225-13-9
- Formula:C46H64N2O13
- Molecular Weight:853.01
InChIKey: DTEDDHSJILGOKQ-DYSHAYIOSA-N
SMILES: O=C(C)O[C@@H]1[C@@H]([C@H](/C=C/O[C@@]2(C)OC3=C(C4=C(C(/C=N/OCCCCCCCC)=C(C(O)=C4C(O)=C3C)NC(/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@H]1C)O)C)O)C)=O)O)C2=O)OC)C
Biological Activity: Rifamycin AF-013 is a derivative of Rifamycin (HY-B1907). Rifamycin AF-013 inhibits DNA polymerase γ by competing with dTTP and template primers for binding. Rifamycin AF-013 exhibits inhibitory activity against Rifampicin (HY-B0272)-resistant RNA polymerase. Rifamycin AF-013 inhibits non-polymerase enzymes including glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and Alkaline phosphatase. Rifamycin AF-013 can be used in research related to Rifampicin-resistant bacterial infections and Ehrlich ascites tumors[1][2].
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Rifamycin AF-013 | Rifamycin AF-013 is a derivative of Rifamycin (HY-B1907). Rifamycin AF-013 inhibits DNA polymerase γ by competing with dTTP and template primers for binding. Rifamycin AF-013 exhibits inhibitory activity against Rifampicin (HY-B0272)-resistant RNA polymerase. Rifamycin AF-013 inhibits non-polymerase enzymes including glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and Alkaline phosphatase. Rifamycin AF-013 can be used in research related to Rifampicin-resistant bacterial infections and Ehrlich ascites tumors. | |||||||||||||||||||||
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References
- [1]. Riva S, et al. Mechanism of action of a rifamycin derivative (AF-013) which is active on the nucleic acid polymerases insensitive to rifampicin. Biochem Biophys Res Commun. 1972 Dec 4;49(5):1263-71.
- [2]. Yagura T, et al. Inhibition of DNA polymerases alpha and gamma by rifamycin derivative AF/013. J Biochem. 1981 Nov;90(5):1397-403.
