353525-62-9
Chemical Structure
CT-2584 mesylate
- CAS No.: 353525-62-9
- Formula:C31H59N5O6S
- Molecular Weight:629.90
InChIKey: RCBJUJRVBGYTEO-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1CCCCCCCCCC(CNCCCCCCCCCCCC)O)=O)N=CN2C.O=S(O)(C)=O
Biological Activity: CT-2584 mesylate is an inhibitor targeting CTP:phosphocholine cytidylyltransferase and MDR1, with antitumor activity. CT-2584 mesylate inhibits de novo synthesis of phosphatidylcholine, induces accumulation of phosphatidic acid and phosphatidylinositol in tumor cells, disrupts and dilates the endoplasmic reticulum and mitochondria, induces apoptosis, and inhibits tumor growth. CT-2584 mesylate induces intravascular hemolysis, has mild hypotensive and antiarrhythmic effects, is an intravenous irritant, and may trigger hypersensitivity reactions when combined with Cremophor EL. CT-2584 mesylate can be used in research on neoplastic diseases, hepatocellular carcinoma, solid tumors, malignant pleural mesothelioma, and cancer[1][2][3][4].
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CT-2584 mesylate | CT-2584 mesylate is an inhibitor targeting CTP:phosphocholine cytidylyltransferase and MDR1, with antitumor activity. CT-2584 mesylate inhibits de novo synthesis of phosphatidylcholine, induces accumulation of phosphatidic acid and phosphatidylinositol in tumor cells, disrupts and dilates the endoplasmic reticulum and mitochondria, induces apoptosis, and inhibits tumor growth. CT-2584 mesylate induces intravascular hemolysis, has mild hypotensive and antiarrhythmic effects, is an intravenous irritant, and may trigger hypersensitivity reactions when combined with Cremophor EL. CT-2584 mesylate can be used in research on neoplastic diseases, hepatocellular carcinoma, solid tumors, malignant pleural mesothelioma, and cancer. | |||||||||||||||||||||
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References
- [1]. Finney RE, et al. Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. Cancer research. 2000 Sep 15;60(18):5204-13.
- [2]. Marucci L, et al. Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice. Hepatology (Baltimore, Md.). 1997 Nov;26(5):1195-202.
- [3]. Cheeseman SL, et al. Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumours. British journal of cancer. 2000 Dec;83(12):1599-606.
- [4]. Shau H, et al. Endogenous natural killer enhancing factor-B increases cellular resistance to oxidative stresses. Free radical biology & medicine. 1997;22(3):497-507. [Content Brief]
