35369-53-0
Chemical Structure
HBED dihydrochloride
- CAS No.: 35369-53-0
- Formula:C20H26Cl2N2O6
- Molecular Weight:461.34
IUPAC Name: 2,2'-(ethane-1,2-diylbis((2-hydroxybenzyl)azanediyl))diacetic acid dihydrochloride
InChIKey: RZDJUOOSLXHIIK-UHFFFAOYSA-N
SMILES: OC1=C(C=CC=C1)CN(CCN(CC2=C(C=CC=C2)O)CC(O)=O)CC(O)=O.Cl.Cl
Biological Activity: HBED dihydrochloride is an iron-chelating antioxidant. HBED dihydrochloride chelates ferrous iron, promotes its oxidation to ferric iron, and blocks superoxide-driven ferric iron reduction, preventing Haber-Weiss/Fenton hydroxyl radical production. HBED dihydrochloride donates H/electrons, undergoes protonation, reduces radical cations, and forms phenoxyl radicals. HBED dihydrochloride exerts cytoprotective effects against peroxide-induced lung fibroblast injury. HBED dihydrochloride crosses the blood-brain barrier and mitochondrial membrane, exhibits iron affinity/selectivity, and induces iron clearance in iron-loaded monkeys. HBED dihydrochloride reduces hippocampal AQP4, microgliosis, oxidative stress, cerebral edema, and hippocampal swelling, and improves motor function/recovery after traumatic brain injury. HBED dihydrochloride can be used in research on iron overload and traumatic brain injury (TBI)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HBED dihydrochloride | 98.0% | HBED dihydrochloride is an iron-chelating antioxidant. HBED dihydrochloride chelates ferrous iron, promotes its oxidation to ferric iron, and blocks superoxide-driven ferric iron reduction, preventing Haber-Weiss/Fenton hydroxyl radical production. HBED dihydrochloride donates H/electrons, undergoes protonation, reduces radical cations, and forms phenoxyl radicals. HBED dihydrochloride exerts cytoprotective effects against peroxide-induced lung fibroblast injury. HBED dihydrochloride crosses the blood-brain barrier and mitochondrial membrane, exhibits iron affinity/selectivity, and induces iron clearance in iron-loaded monkeys. HBED dihydrochloride reduces hippocampal AQP4, microgliosis, oxidative stress, cerebral edema, and hippocampal swelling, and improves motor function/recovery after traumatic brain injury. HBED dihydrochloride can be used in research on iron overload and traumatic brain injury (TBI). | ||||||||||||||||||||
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References
- [1]. Samuni AM, et al. Multifunctional antioxidant activity of HBED iron chelator. Free radical biology & medicine. 2001 Jan 15;30(2):170-7.
- [2]. Khalaf S, et al. Unique Properties Associated with the Brain Penetrant Iron Chelator HBED Reveal Remarkable Beneficial Effects after Brain Trauma. Journal of neurotrauma. 2019 Jan 01;36(1):43-53.
