3545-76-4
Chemical Structure
Inosine 3',5'-cyclic monophosphate
Synonym(s): cIMP
- CAS No.: 3545-76-4
- Formula:C10H11N4O7P
- Molecular Weight:330.19
IUPAC Name: 9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3,9-dihydro-6H-purin-6-one
InChIKey: DMJWGQPYNRPLGA-KQYNXXCUSA-N
SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@]4([C@]1(OP(=O)(O)OC4)[H])[H]
Biological Activity: Inosine 3',5'-cyclic monophosphate (cIMP) is an endogenous cyclic nucleotide second messenger molecule generated by guanylate cyclase (sGC) that mediates vasoconstrictive responses in vascular tissue. Inosine 3',5'-cyclic monophosphate-mediated vasoconstrictive effects depend on an intact eNOS‑NO‑sGC signaling axis, and PDE5 and PDE4A mediate enhanced metabolism of cGMP and cAMP, thereby relieving the masking of the vasoconstrictive activity of cIMP. Inosine 3',5'-cyclic monophosphate participates in the regulation of vascular tone homeostasis and the signaling process of hypoxia-induced coronary vasospasm. Inosine 3',5'-cyclic monophosphate can be used for mechanistic studies of vascular homeostasis and hypoxic coronary vasospasm[1][2].
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Inosine 3',5'-cyclic monophosphate | Inosine 3',5'-cyclic monophosphate (cIMP) is an endogenous cyclic nucleotide second messenger molecule generated by guanylate cyclase (sGC) that mediates vasoconstrictive responses in vascular tissue. Inosine 3',5'-cyclic monophosphate-mediated vasoconstrictive effects depend on an intact eNOS‑NO‑sGC signaling axis, and PDE5 and PDE4A mediate enhanced metabolism of cGMP and cAMP, thereby relieving the masking of the vasoconstrictive activity of cIMP. Inosine 3',5'-cyclic monophosphate participates in the regulation of vascular tone homeostasis and the signaling process of hypoxia-induced coronary vasospasm. Inosine 3',5'-cyclic monophosphate can be used for mechanistic studies of vascular homeostasis and hypoxic coronary vasospasm. | |||||||||||||||||||||
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References
- [1]. Mitidieri E, et al. Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone. British journal of pharmacology. 2021 Sep;178(18):3765-3782.
- [2]. Nan Y, et al. PDE1 or PDE5 inhibition augments NO-dependent hypoxic constriction of porcine coronary artery via elevating inosine 3',5'-cyclic monophosphate level. Journal of cellular and molecular medicine. 2020 Dec;24(24):14514-14524.
