357425-68-4
Chemical Structure
CP-601932
Synonym(s): (1S,5R)-CP-601927
- CAS No.: 357425-68-4
- Formula:C12H12F3N
- Molecular Weight:227.23
IUPAC Name: (1S,5R)-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine
InChIKey: RNOBTWYQAWEZHH-SFYZADRCSA-N
SMILES: FC(F)(C1=CC=C([C@@H]2C[C@H]3CNC2)C3=C1)F
Biological Activity: CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21 nM; EC50=~ 3 μM). CP-601932 has the same high-binding affinity at α4β2 nAChR (Ki=21 nM) and an order of magnitude lower affinity for α6 and α7 nAChR subtypes. CP-601932 selectively decreases ethanol but not sucrose consumption and operant self-administration following long-term exposure. CP-601932 can penetrate the CNS[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CP-601932 | 99.30% | CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21 nM; EC50=~ 3 μM). CP-601932 has the same high-binding affinity at α4β2 nAChR (Ki=21 nM) and an order of magnitude lower affinity for α6 and α7 nAChR subtypes. CP-601932 selectively decreases ethanol but not sucrose consumption and operant self-administration following long-term exposure. CP-601932 can penetrate the CNS. | ||||||||||||||||||||
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