35750-48-2
Chemical Structure
Geranylgeranoic acid
- CAS No.: 35750-48-2
- Formula:C20H32O2
- Molecular Weight:304.47
InChIKey: SZNLKILVMCHHSD-OZFNKYQOSA-N
SMILES: C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/C(O)=O
Biological Activity: Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC50 value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Geranylgeranoic acid | 98.1% | Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC50 value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis. | ||||||||||||||||||||
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References
- [1]. Ungur N, et al. Synthetic studies on natural diterpenoid glyceryl esters[J]. Tetrahedron, 2000, 56(16): 2503-2512.
- [2]. Shidoji Y, et al. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Biochem Biophys Res Commun. 1997 Jan 3;230(1):58-63. [Content Brief]
- [3]. Sakane C, et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. Biochem Biophys Res Commun. 2014 Jan 31;444(1):24-9. [Content Brief]
