35988-27-3
Chemical Structure
Kutkoside
- CAS No.: 35988-27-3
- Formula:C23H28O13
- Molecular Weight:512.46
InChIKey: JANLDILJJLTVDB-KVBCGVIQSA-N
SMILES: O=C(C1=CC(OC)=C(C=C1)O)OC[C@@]23[C@]4([H])[C@](C=CO[C@H]4O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)([H])[C@@H]([C@]2([H])O3)O
Biological Activity: Kutkoside is an orally active iridoid glycoside mixture composed of picroside II, picroside IV, and 6-ferulloylcatalpol. Kutkoside exerts antioxidant effects by targeting hepatic and lysosomal enzymes, inhibiting Xanthine Oxidase (IC50 = 354.6 μM) and lipid peroxidation, and downregulates MMP-1/2/9/13 to suppress tumor invasion and inflammatory mediators. Kutkoside can be used in research on D-galactosamine-induced liver injury and breast cancer[1][2][3][4].
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Kutkoside | Kutkoside is an orally active iridoid glycoside mixture composed of picroside II, picroside IV, and 6-ferulloylcatalpol. Kutkoside exerts antioxidant effects by targeting hepatic and lysosomal enzymes, inhibiting Xanthine Oxidase (IC50 = 354.6 μM) and lipid peroxidation, and downregulates MMP-1/2/9/13 to suppress tumor invasion and inflammatory mediators. Kutkoside can be used in research on D-galactosamine-induced liver injury and breast cancer. | |||||||||||||||||||||
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References
- [1]. Dwivedi Y, et al. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacology & toxicology. 1992 Nov;71(5):383-7.
- [2]. Chander R, et al. Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions. Biochemical pharmacology. 1992 Jul 07;44(1):180-3.
- [3]. Bhandari P, et al. Online HPLC-DPPH method for antioxidant activity of Picrorhiza kurroa Royle ex Benth. and characterization of kutkoside by ultra-performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry. Indian journal of experimental biology. 2010 Mar;48(3):323-8.
- [4]. Rathee D, et al. Iridoid glycosides-Kutkin, Picroside I, and Kutkoside from Picrorrhiza kurroa Benth inhibits the invasion and migration of MCF-7 breast cancer cells through the down regulation of matrix metalloproteinases: 1st Cancer Update[J]. Arabian Journal of Chemistry, 2013, 6(1): 49-58.
