360769-22-8
360769-22-8
Chemical Structure
Dihydrouracil-13C4,15N2
Synonym(s): 5,6-Dihydrouracil-13C4,15N2
- CAS No.: 360769-22-8
- Formula:13C4H615N2O2
- Molecular Weight:120.06
IUPAC Name: (R)-3-(3-hydroxyphenyl)-4-methyl-2-(4-((1-propylazetidin-3-yl)methoxy)phenyl)-2H-chromen-6-ol
InChIKey: OIVLITBTBDPEFK-IDEBNGHGSA-N
SMILES: O=[13C]1[15NH][13C]([15NH][13CH2][13CH2]1)=O
Biological Activity: Dihydrouracil-13C4,15N2 is the 13C and 15N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
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Dihydrouracil-13C4,15N2 | 98% | Dihydrouracil-13C4,15N2 is the 13C and 15N labeled Dihydrouracil. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769. [Content Brief]
- [3]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744. [Content Brief]
