361465-74-9
361465-74-9
Chemical Structure
AS1604498
- CAS No.: 361465-74-9
- Formula:C19H17N3O2
- Molecular Weight:319.36
IUPAC Name: N-(3-(1H-imidazol-1-yl)propyl)-5-(phenylethynyl)furan-2-carboxamide
InChIKey: GFFHGAGBUQXRIL-UHFFFAOYSA-N
SMILES: O=C(NCCCN1C=NC=C1)C=2OC(C#CC=3C=CC=CC3)=CC2
Biological Activity: AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia[1].
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AS1604498 | AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia. | |||||||||||||||||||||
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