3649-76-1
Chemical Structure
Ebelin lactone
- CAS No.: 3649-76-1
- Formula:C30H46O3
- Molecular Weight:454.68
InChIKey: TUWRBFMVJOJFCL-SZGKVTBMSA-N
SMILES: C[C@]12[C@@]3(COC(C3)=O)[C@H](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)/C=C(C)/C=C/C=C(C)/C
Biological Activity: Ebelin lactone is an acetylcholinesterase (AChE) inhibitor, with a Ki of 0.45 μM against human M1 muscarinic acetylcholine receptor (mAChR) and a Ki of 4.21 μM against human 5-HT2A serotonin receptor. Ebelin lactone binds to the allosteric cavity above the orthosteric site of M1 via nonpolar interactions with subtype-selective residues. Ebelin lactone binds to the cavity between transmembrane helices 4 and 5 of 5-HT2A through nonpolar interactions with orthosteric site residues. Ebelin lactone exhibits free radical scavenging activity, inhibits cancer cell proliferation, and regulates memory and cognitive processes by interacting with M1 and 5-HT2A receptors. Ebelin lactone can be used in studies related to Alzheimer's disease, breast cancer and colorectal cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ebelin lactone | 96.0% | Ebelin lactone is an acetylcholinesterase (AChE) inhibitor, with a Ki of 0.45 μM against human M1 muscarinic acetylcholine receptor (mAChR) and a Ki of 4.21 μM against human 5-HT2A serotonin receptor. Ebelin lactone binds to the allosteric cavity above the orthosteric site of M1 via nonpolar interactions with subtype-selective residues. Ebelin lactone binds to the cavity between transmembrane helices 4 and 5 of 5-HT2A through nonpolar interactions with orthosteric site residues. Ebelin lactone exhibits free radical scavenging activity, inhibits cancer cell proliferation, and regulates memory and cognitive processes by interacting with M1 and 5-HT2A receptors. Ebelin lactone can be used in studies related to Alzheimer's disease, breast cancer and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Devaraj Reddy KN, et al. Enhanced bioavailability and efficacy of bacopa extract and ebelin lactone: preparation and biological evaluation. Asian J Biol. 2024;20(5):23-33.
- [2]. Kawai K, et al. A new sapogenin in the saponins of Zizyphus jujuba, Hovenia dulcis and Bacopa monniera. Phytochemistry. 1974;13:2829-2832.
- [3]. Ramasamy S, et al. In Silico and In Vitro Analysis of Bacoside A Aglycones and Its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri. PloS one. 2015;10(5):e0126565. [Content Brief]
