36622-40-9
Chemical Structure
(-)-Gallopamil
Synonym(s): (-)-Methoxyverapamil
- CAS No.: 36622-40-9
- Formula:C28H40N2O5
- Molecular Weight:484.63
IUPAC Name: (S)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile
InChIKey: XQLWNAFCTODIRK-NDEPHWFRSA-N
SMILES: N#C[C@](CCCN(C)CCC1=CC=C(C(OC)=C1)OC)(C2=CC(OC)=C(C(OC)=C2)OC)C(C)C
Biological Activity: (-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics[1][2].
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(-)-Gallopamil | (-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics. | |||||||||||||||||||||
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References
- [1]. Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. [Content Brief]
- [2]. Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. [Content Brief]
