367518-31-8
Chemical Structure
AR-M1896
- CAS No.: 367518-31-8
- Formula:C54H81N13O14
- Molecular Weight:1136.30
IUPAC Name: (S)-2-((S)-2-((2S,3R)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-3-hydroxybutanamido)-4-methylpentanamido)-N1-((2S,5S,11S,14S,17S)-17-carbamoyl-1-hydroxy-11-(4-hydroxybenzyl)-14-isobutyl-5,19-dimethyl-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazaicosan-2-y
InChIKey: SUJPPMXJCZETOA-ZKEPBWIVSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@]([C@H](O)C)([H])NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)=O
Biological Activity: AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain[1][2].
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AR-M1896 | AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain. | |||||||||||||||||||||
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References
- [1]. Liu HX, et al. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9960-4. [Content Brief]
- [2]. Serebryakova L, et al. Galanin and its N-terminal fragments reduce acute myocardial infarction in rats. Peptides. 2019 Jan;111:127-131. [Content Brief]
